OC-0380: Cell cycle checkpoint modulates radiotherapy fraction size sensitivity in normal and malignant cells
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چکیده
منابع مشابه
Normal cell cycle and checkpoint responses in mice and cells lacking Cdc25B and Cdc25C protein phosphatases.
The Cdc25 family of protein phosphatases positively regulates cell division by activating cyclin-dependent protein kinases (CDKs). In humans and rodents, there are three Cdc25 family members--denoted Cdc25A, Cdc25B, and Cdc25C--that can be distinguished based on their subcellular compartmentalizations, their abundances and/or activities throughout the cell cycle, the CDKs that they target for a...
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Although most brain cells are postmitotic, small populations of progenitor or stem cells can divide throughout life. These cells are believed to be the most likely source for primary brain malignancies including gliomas. Such tumors share many common features with nonmalignant glial cells but, because of their insidious growth, form cancers that are typically incurable. In studying the growth r...
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Every second of our lives, millions of blood cells are destroyed and must be regenerated. This regeneration is accomplished by hematopoietic stem cells (HSCs), the only cells that throughout life are able to both produce the required new cells of all blood lineages and maintain their own numbers. Obviously, the regulation of HSC fate decisions between remaining in the stem cell state (selfrenew...
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Purpose: To investigate the effect of different methods of synchronization on sheep granulosa cell cycle. Materials and Methods: Granulosa cells were aspirated from ovarian follicles and plated in a DMEM medium containing 15% FBS. Upon 70-80% confluency, the medium of the primarycultured as well as the passaged-5 cells were replaced with the medium containing either 0.5% FBS for 24, 48 and 72 h...
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Vertebrate homologs of yeast spindle assembly checkpoint proteins are localized to kinetochores and may act as a sensor for proper chromosome attachment to the mitotic spindle.
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ژورنال
عنوان ژورنال: Radiotherapy and Oncology
سال: 2018
ISSN: 0167-8140
DOI: 10.1016/s0167-8140(18)30690-x